Webb5 juni 2024 · Moreover, compound 72 exhibited strong neuroprotective efficacy in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN) without any overt toxicity, which renders it a promising candidate for the development of novel neuroprotective agents. Graphical abstract Download : Download high-res image (349KB) Webb24 okt. 2024 · SARM1 inhibitors are a potential oral treatment to slow disease …

Selective inhibitors of SARM1 targeting an allosteric cysteine in …

Webb2 mars 2024 · In recent years, there has been growing interest in SARM1 as a potential breakthrough drug target for treating various pathologies of axon degeneration. SARM1-mediated axon degeneration relies on its TIR domain NADase activity, but recent structural data suggest that the non-catalytic ARM domain could also serve as a pharmacological … Webb22 aug. 2024 · Evidence is provided for an alternative allosteric mode of controlling SARM1 function through the chemical proteomic discovery of a druggable cysteine in the autoregulatory ARM domain of the enzyme. Significance The discovery of ways to protect axons from degeneration has the potential to benefit a wide range of neurodegenerative … free maximum cloud storage

Pharmacological SARM1 inhibition protects axon …

Webb16 okt. 2024 · Purpose This review provides an update on the current clinical, … WebbNational Center for Biotechnology Information Webb8 apr. 2014 · OBJECTIVE: Common molecular pathways leading to degeneration of distal axons in chemotherapy-induced peripheral neuropathy (CIPN) are unknown. We examined the development of CIPN in mice with genetic deletion of Sarm1 gene and compared it to wild type littermates BACKGROUND: Recently, dSarm and mouse homologue Sarm1 … free maximum ride books download